TEAM2- Molecular and cellular pathophysiology of metabolic diseases

The team 2 “Molecular and cellular pathophysiology of metabolic diseases” is headed by Jean-Sébastien Annicotte (jean-sebastien.annicotte@inserm.fr)

Our aim is to develop innovative strategies to elucidate through disease modelling still hidden molecular mechanisms of metabolic and renal disorders, and, taking advantage of these basic research data, to contribute to develop innovative treatments tailored to patient’s specific cause of disease. To achieve its goals, team #2 uses integrated functional approaches from cellular and mouse models to decipher new path involved in the physiopathology of diabetes and chronic kidney disease (two commonly associated diseases), and will find avenues to correct (reprogram) it.

T2D is characterized by permanent high blood glucose levels, due to inadequate pancreatic betacell function in the face of multi-tissue systemic insulin resistance (IR). Both hyperglycemia and insulin resistance are causatively involved in T2D long-term complications, such as NASH and chronic kidney disease. Team #2 comprehensively includes recognized PIs in beta cell, adipose tissue and kidney disease biology (Jean-Sébastien Annicotte, Christophe Breton and Régine Chambrey). They will assess:

  • How insulin secretion is physiologically regulated in pancreatic islets, why insulin secretion/beta-cell mass is impaired/decreased during the course of T2D and whether we can improve beta-cell function using novel small molecules.
  • The molecular mechanisms involved in insulin resistance in rodent adipose tissue and the interest of induced pluripotent stem cells to correct metabolic disorders.
  • The molecular and physiological mechanisms involved in the different monogenic form of diabetes identified by team #1 studies.
  • The molecular mechanisms of the progression of chronic renal disease related to acidosis and insulin resistance in the context of diabetes.

 

 

 

The team’s research axes are(follow the links for more details)

i/ From basic research to new small molecules to treat diabetes at the betacell level

ii/ Fighting Insulin resistance through a better understanding of adipose tissue biology

iii/ Contribution of acidosis to chronic kidney disease and related disorders

 

 

 

Members:

Senior scientists

  • Jean-Sébastien ANNICOTTE, Group leader, CRCN INSERM
  • Christophe BRETON, PU Univ Lille
  • Régine CHAMBREY, CR CNRS

Post-docs

  • Marie-Jennifer BARAKA-VIDOT, Post-Doc CNRS
  • Émilie COURTY, Post-Doc Pasteur Institute of Lille
  • Clément DELANNOY, Post-Doc Univ Lille
  • Frederik OGER, Post-Doc Univ Lille

Engineer/technicians

  • Charlène CARNEY, AI INSERM
  • Maeva MORENO, IE INSERM
  • Jessica MONTAIGNE, Technicienne Univ Lille
  • Laure ROLAND, Assistante Ingénieure Institut Pasteur

PhD students

  • Etienne BLANC, PhD student
  • Cyril BOUROUH, PhD student
  • Florine BORNAQUE, PhD student
  • Arnaud DANCE, PhD student
  • Yasmina KAHOUL, PhD student
  • Leonid PLINER, PhD student
  • Nawel ZAIBI, PhD student

 

 

Former Members :

  • Carine De Bettignies, Engineer
  • Xavier GROMADA, PhD
  • Sarah Hannou, PhD
  • Talha Rashid, PhD
  • Elisabet Salas, PhD
  • Nabil RABHI, PhD
  • Bryan THIROUX, Technician